ReviewJournal of neurochemistry2025
Keratan Sulfate Is a Multifunctional Brain Glycosaminoglycan With Instructive Capabilities.
Review in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling.Journal of neuroscience research · 2026Review
- Keratan Sulfate Is a Multifunctional Brain Glycosaminoglycan With Instructive Capabilities.Journal of neurochemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Keratan sulfate (KS) is a glycosaminoglycan (GAG) with unique functions including electroconductive properties that support neurotransmission. KS-proteoglycans contribute to tissue stabilization and functional organization, and have diverse interactive properties with cytokines, growth factors, morphogens, neuregulatory proteins, and neuron receptors that control the formation and function of neural networks. As side chain components of a diverse range of brain proteoglycans, KS assists neural development and axonal guidance, storage and transport of neurotransmitters in synaptic vesicles, neurotransduction, synaptic plasticity, cognition, and memory in perineuronal nets, neuronal proliferation, and differentiation. KS is thus a multifunctional instructive brain GAG with essential roles to play in brain function and homeostasis, with instructive roles in the assembly and repair of functional network structures from secreted molecules produced by glial cells and neurons in the assembly of transmitter and effector receptors and ion channels which affect brain function and neuronal control. KS is a component of neuropils in white matter; however, its specific roles in the function of this tissue have yet to be determined. Dysfunctional KS-mediated cell signaling, however, may predispose to the development of a number of neurological disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.