SynthesisJournal of the European Academy of Dermatology and Venereology : JEADV2026
Skin graft bolstered by negative pressure therapy in chronic wounds: A systematic review.
Synthesis in Journal of the European Academy of Dermatology and Venereology : JEADV, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role of Negative Pressure Therapy in Diabetic Foot Ulcer: A Meta-Analysis.Journal of diabetes · 2026Pooled it
- Skin graft bolstered by negative pressure therapy in chronic wounds: A systematic review.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Pooled it
- Multifunctional Silk Fibroin-Curcuminoid Films Combining Regenerative and Antioxidant Properties with pH Sensing for Wound Dressing Applications.Biomimetics (Basel, Switzerland) · 2026Article
- Early Outcomes and Complications of Skin Graft Reconstruction for Complex Wounds at a Tertiary Hospital: A Single-Centre Study in Oman.Diseases (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic ulcers represent a significant burden for patients, often requiring advanced therapeutic interventions. Skin grafting is a critical treatment option, yet the risk of graft failure remains substantial. Negative pressure wound therapy (NPWT) has demonstrated efficacy in enhancing graft survival in acute wounds, but its effectiveness in chronic ulcers remains underexplored.
objectivesThis systematic review aimed to evaluate the efficacy of NPWT in bolstering skin grafts for the treatment of chronic ulcers.
methodsWe conducted this systematic literature review using the scientific databases PUBMED, COCHRANE and EMBASE. Studies involving skin grafts supported by NPWT for chronic wounds were included, while those focussing on acute wounds, burns or post-surgical wounds were excluded. Data on patient demographics, wound characteristics, NPWT parameters and graft outcomes were extracted and analysed.
resultsA total of 21 articles, encompassing 186 patients, were included. The maximal graft uptake (≥95%) was observed in 33% of patients, while 77% achieved a graft uptake of ≥90%. The mean graft take was 92% (89.7, 93.5, 95% confidence interval). Complete recovery was achieved in 79% of patients, with a mean recovery time of 73 days. Complete response without recurrence was noticed in 38% of the cases, with a mean time without recurrence of 197 days. Exploratory analyses indicated higher graft take rates in patients under 65 years, males, diabetics and those without arterial disease. Venous and neurotrophic ulcers also showed superior graft uptake.
conclusionsNPWT appears to significantly enhance graft survival in chronic ulcers, with an excellent safety and tolerance profile. As there was no control group, historical controls of graft take without NPWT were used. Short-term NPWT application (less than 1 week) is recommended for optimal outcomes. These findings suggest that NPWT should be considered a preferred method for securing skin grafts in chronic ulcer management. PROSPERO registration number: CRD420251005192.
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