Evidence map›Paper›PMID 40862294›Full record

ArticleMediators of inflammation2025

GPR34 Stabilized by Deubiquitinase USP8 Suppresses Ferroptosis of ATC.

Bokang Yan, Jiaxing Guo, Meiyuan Huang, Zhecheng Li, Jingyue Sun, Hailong Tan, Weiwei Lai, Shi Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bokang YanInstitute of Large-Scale Scientific Facility and Centre for Zero Magnetic Field Science, Beihang University, Beijing 100191, China.ORCID https://orcid.org/0009-0002-9825-8802
Jiaxing GuoDepartment of Hematology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 412007, Hunan, China.
Meiyuan HuangDepartment of Pathology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 412007, Hunan, China.
Zhecheng LiDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.ORCID https://orcid.org/0000-0002-7678-5639
Jingyue SunDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410078, Hunan, China.
Hailong TanDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Weiwei LaiHunan Provincial Key Laboratory of Pediatric Orthopedics, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha 410007, Hunan, China.ORCID https://orcid.org/0009-0009-0890-5537
Shi ChangNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.ORCID https://orcid.org/0000-0001-5291-0151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G protein-coupled receptor 34 (GPR34) is an orphan receptor within the G protein-coupled receptor (GPCR) superfamily, and its specific role in anaplastic thyroid carcinoma (ATC) remains to be elucidated. In this study, we observed that GPR34 was aberrantly upregulated in ATC and the deletion of GPR34 inhibited tumor progression both in vivo and in vitro. Additionally, suppression of GPR34 promoted ferroptosis in ATC cells. We further identified USP8 as a deubiquitinase (DUB) for GPR34, and the effects induced by GPR34 deletion were reversible through USP8 overexpression. Moreover, targeting USP8 with the inhibitor DUB-IN-3 effectively restrained ATC growth. Together, the present study revealed the role of GPR34 in ATC progression and ferroptosis, discovered its corresponding DUBs, and proposed GPR34 as a promising target for ATC therapy.

Indexed as

EndopeptidasesFerroptosisReceptors, G-Protein-CoupledThyroid Carcinoma, AnaplasticThyroid NeoplasmsUbiquitin ThiolesteraseAnimalsCell Line, TumorCell ProliferationEndosomal Sorting Complexes Required for TransportHumansMiceMice, NudeEndopeptidasesEndosomal Sorting Complexes Required for TransportReceptors, G-Protein-CoupledUbiquitin ThiolesteraseUSP8 protein, humanATCDUB-IN-3ferroptosisGPR34USP8

Identifiers

PMID40862294
PMCPMC12377955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.