ArticleJournal of multidisciplinary healthcare2025
Association Between Gastroesophageal Reflux Disease, Barrett's Esophagus and Ear Disorders: A Mendelian Randomization Study.
Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Objective: This study aims to examine the correlation between gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), and ear disorders using Mendelian randomization (MR). Methods: For GERD, BE, and ear disorders, GWAS genetic data from individuals of European ancestry in the IEU GWAS database (https://gwas.mrcieu.ac.uk/) was utilized in this study. Three MR methods were applied for preliminary analysis, with causal estimates determined using the inverse variance weighted method. Sensitivity analysis was conducted to assess heterogeneity and pleiotropy. Results: Potential effects of genetically predicted GERD on ear disorders were identified in this study. GERD was associated with Ménière's disease (OR = 1.334, 95% CI: 1.073-1.671, Conclusion: Under MR assumptions, the findings of this study indicate that GERD may increase the risk of tinnitus, Ménière's disease, vestibular dysfunction, and sensorineural hearing loss.
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