Evidence map›Paper›PMID 40862176›Full record

ArticleAdvanced biomedical research2025

The Multi-Voxel MRS of Glioma: Glycine is a Suitable Biomarker for Tumor Grading.

Hossein Taheri, Simin Hemati, Reza Moghareabed, Mohammadbagher Tavakoli, Ali Forouzmehr, Safura Mozafari, Negar Abdi, Yasaman Nilie, Hamed Taheri

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Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hossein TaheriMedical Physics Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Simin HematiRadiation Oncology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Reza MoghareabedRadiation Oncology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammadbagher TavakoliMedical Physics Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Ali ForouzmehrRadiology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Safura MozafariDepartment of Emergency Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Negar AbdiMedical Physics Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Yasaman NilieAnatomy Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Hamed TaheriAnatomical Department, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The goal of this study was to evaluate the role of different metabolites such as glycine, choline (Cho), NAA, and creatinine (Cr) in the grading of glioma in the multi-voxel MRS. Materials and Methods: Thirty-five patients who suffered from glioma, according to their pathologic and clinical findings, were included in this study. In this work, the paraffin-embedded brain tissues of patients were studied by four expert pathologists. Then, the contrast enhancement T1-weighted (T Results: The correlation between glycine and other studied metabolites (Gly/NAA, Gly/Cho, Gly/Cr) for high-grade patients (4.28 ± 1.23, 4.12 ± 1.74, and 4.56 ± 1.98, respectively) was higher than low grades (2.69 ± 1.17, 2.73 ± 1.26, and 2.41 ± 1.34, respectively) ( Conclusion: Evaluation of the correlation between glycine and other metabolites for glioma tumors in multi-voxel MRS is proposed because it would seem that glycine may have a positive role in glioma grading.

Indexed as

GliomaglycineMRStumor grading

Identifiers

PMID40862176
PMCPMC12373135

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