ArticleAdvanced biomedical research2025
Aminoguanidine Improved Liver Function and Attenuated Oxidative Stress in Hypothyroid Rats by Propylthiouracil.
Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- 10.6 μm laser moxibustion can improve oxidative stress and abnormal energy metabolism in liver of hypothyroidism rats through Nrf2/HO-1 and Nrf2/PGC-1α/TFAM pathways.Lasers in medical science · 2026Article
- The Effect of Aminoguanidine on Fibrinogen Gene Expression and Oxidative Stress Biomarkers in the Liver Tissue of a Streptozotocin-Induced Diabetic Rat ModelTurkish journal of pharmaceutical sciences · 2026Article
- Aminoguanidine attenuates arsenic-induced hepatic oxidative stress: Dose-dependent effects in a mouse model.Toxicology reports · 2025Article
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Authors and funding
8 authors.
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Abstract
Background: Hypothyroidism negatively affects liver function, which might be due to nitric oxide (NO) overproduction, oxidative stress, and fibrosis. Aminoguanidine (AMG) as an inducible NO synthase (iNOS) inhibitor attenuates NO and shows antioxidant effects. This study aimed to evaluate the protective effect of AMG against liver damage caused by hypothyroidism. Materials and Methods: The rats were divided into 5 groups and treated by (1) vehicle, (2) propylthiouracil (PTU, 0.05% in drinking water) to induce hypothyroidism, (3-5) PTU + AMG (10 mg/kg), PTU + AMG (20 mg/kg), and PTU + AMG (30 mg/kg). The rats were given AMG intraperitoneally for 6 weeks. The blood concentration of T4, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALK-P), albumin, and total protein was estimated. The hepatic level of malondialdehyde (MDA), total thiol group, superoxide dismutase (SOD), and catalase (CAT) was also measured. In addition, liver fibrosis was evaluated using Masson's trichrome method. Results: Hypothyroidism induced by PTU elevated the concentration of MDA, ALT, AST, and ALK-P ( Conclusion: The results suggest that AMG effectively ameliorates liver fibrosis and functional impairment resulting from hypothyroidism by reinforcing the antioxidative potential.
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