SynthesisFrontiers in endocrinology2025
Mechanisms and traditional Chinese medicine therapeutics for primary osteoporosis: an integrated perspective.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coumarins in musculoskeletal health: a systematic review.Frontiers in nutrition · 2026Pooled it
- Research Progress on Mechanisms of Milk-Derived Functional Components in Regulating Bone Health and the Gut-Bone Axis.Nutrients · 2026Review
- Mechanistic and Clinical Perspectives on Traditional Chinese Medicine in Thyroid Cancer Management.Biomolecules & therapeutics · 2026Review
- Traditional Chinese medicine regulating Wnt/β-catenin and OPG/RANKL/RANK pathways in osteoporosis: a narrative review based on bone coupling and pathological subtype differences.Frontiers in medicine · 2026Review
- Characterization of the integrated gut microbiota and metabolite profiles in osteoporosis patients with different traditional Chinese medicine syndromes.Frontiers in microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary osteoporosis (POP) is a systemic skeletal disorder characterized by compromised bone microarchitecture. With the progression of population aging trends, POP has garnered increasing societal concern as a major public health challenge. Contemporary research reveals that POP pathogenesis involves intricate interactions among endocrine regulation, genetic predisposition, and neuromodulation pathways. Recent advances in Traditional Chinese Medicine (TCM) investigations have demonstrated its unique therapeutic advantages in POP management through multi-target regulatory mechanisms. This review systematically examines the molecular pathogenesis of POP and deciphers potential therapeutic mechanisms of TCM for POP involving bone metabolism regulation, including herbal compound-induced osteoblast activation, osteoclast inhibition, and extracellular matrix remodeling. By integrating evidence from pharmacokinetic studies and clinical trials, this analysis provides scientific validation for the efficacy and pharmacological rationale of TCM interventions, while proposing novel clinical intervention strategies that synergize traditional therapeutic wisdom with modern precision medicine approaches. This comprehensive review was conducted based on a systematic literature search across PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data databases, encompassing original research articles and reviews published between 2004 and 2024. The search focused on the pathogenesis of primary POP (including hormonal regulation, genetic factors, neuromodulation) and the therapeutic effects of Traditional Chinese Medicine (TCM) (single herbs and formulas). Studies were selected according to predefined inclusion (clear relevance, robust methodology) and exclusion criteria (case reports, duplicates, low-quality studies). Key findings from the included literature were synthesized and critically analyzed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.