ArticleFrontiers in endocrinology2025
Risk factors for renal impairment in primary aldosteronism: a retrospective study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Risk factors for postoperative renal function decline after laparoscopic adrenalectomy in patients with primary aldosteronism: a retrospective cohort study.Gland surgery · 2026Article
- Primary Hyperaldosteronism: Epidemiology, Diagnosis, and Clinical Associations.Epidemiologia (Basel, Switzerland) · 2026Review
- Primary aldosteronism beyond laterality: integrating subtype assignment with outcome-oriented risk stratification.Frontiers in endocrinology · 2026Review
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11 authors.
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Abstract
Objective: This study aimed to investigate the risk factors associated with renal impairment among patients diagnosed with primary aldosteronism (PA). Methods: This study enrolled 147 PA patients who were initially classified into hypokalemic (n=56) and normokalemic (n=91) groups according to serum potassium levels, followed by subgroup stratification using combined adrenal venous sampling (AVS) and computed tomography (CT) diagnostic data. For comparison, 280 patients diagnosed with essential hypertension (EH) served as the control group. Data on general patient characteristics and biochemical markers from blood and urine samples were collected. The analysis involved comparing these indicators across groups and performing binary logistic regression to identify potential risk factors for renal damage. Results: When compared to the EH group, the PA group had lower serum potassium and heart rate ( Conclusion: This study demonstrates that renal impairment is more pronounced in PA patients than in those with EH. Notably, the classic APA subtype exhibits particularly severe damage, specifically manifested by elevated urinary microalbumin excretion. Furthermore, concomitant hypokalemia in PA patients is associated with more severe renal impairment. Hypokalemia and increased 24-hour urinary potassium excretion emerge as key risk factors for renal damage within this patient population.
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