ArticleFrontiers in endocrinology2025
Main differential endometrial microbiota associated with recurrent implantation failure: a case control study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Distinctive reproductive tract microbial characteristics associated with infertility in women: a systematic review and meta-analysis.Frontiers in cellular and infection microbiology · 2026Pooled it
- Optimizing the Endometrial Factor in Recurrent Implantation Failure: From Established Diagnostics to Mechanism-Informed Management.Journal of clinical medicine · 2026Review
- Vaginal Microbiome Profiles and Reproductive Outcomes: Implications for Natural Conception and Assisted Reproduction.Cureus · 2026Review
- Endometrial Microbiome Profiles in Women Evaluated for Infertility or Recurrent Miscarriage: A Single-Center Descriptive Study.Diagnostics (Basel, Switzerland) · 2026Article
- Decoding the reproductive microbiome: enabling clinical and biological insights through machine and deep learning.Frontiers in endocrinology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Recurrent implantation failure (RIF) is a major challenge in reproductive medicine, and emerging evidence suggests that alterations in the endometrial microbiota may play a critical role in its pathogenesis. To identify the main differential endometrial microbiota associated with RIF and to establish threshold values for their relative abundance. Methods: This case-control study was conducted in the Departments of Obstetrics, Gynecology, and Reproductive Medicine at two large hospitals. From March to December 2023, the study recruited 17 infertile patients with RIF (Group A, cases), 19 healthy non-pregnant women (Group B, controls), and 20 healthy pregnant women (Group C, controls). Demographic information, medication history, clinical data, and endometrial tissue samples were collected. Endometrial microbiota of all participants was profiled using 16S rRNA gene sequencing. Results: The richness of endometrial microbiota in Group A was significantly lower compared to both control groups ( Discussion:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.