ArticleRSC advances2025
Surface charge dictates the mechanism of cellular uptake of fluorescent amine passivated carbon dots.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
The surface charge of carbon dots (CDs) governs cellular uptake; however, studies seldom compare CDs with similar physico-chemical properties thereby introducing confounding variables. Here, we investigate how the surface charge of amine-passivated carbon dots with similar optical and chemical properties influences their uptake in human cells. We synthesized CDs using citric acid diethylenetriamine (DT3) or pentaethylenehexamine (PH6) using microwave-assisted synthesis. Extensive characterization confirmed their physico-chemical and optical properties. Ion exchange column chromatography was used to separate CDs into fractions with surface charges ranging from -35 mV to +7 mV, which were then added to HeLa cells. FT-IR analysis shows a visible increase of the amide stretch at 1646 cm
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