ArticleRSC advances2025
Application of an innovative isoniazid-loaded biomimetic mineralized bone collagen scaffold in bone defect treatment.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bone defects, arising from various causes such as trauma, infection, tumor, surgical debridement, and congenital diseases, pose challenges to the natural self-healing process of bone tissue. Large-scale bone defects may lead to non-healing of the bone, and they need to be repaired through surgery using transplant materials. While graft materials serve as scaffolds for cell attachment and growth, infectious bone defects, like tuberculosis of the bone and joint, require anti-infective therapy concurrent with defect repair. This study aimed to construct a nano-scale drug-loaded mineralized collagen scaffold and assess its physicochemical, anti-infective, and osteogenic properties. By using isoniazid, hydroxyapatite and type I collagen, we achieved assembly through biomimetic mineralization principle and prepared a drug-loaded mineralized collagen scaffold. The scaffolds' surface morphology and composition were analyzed
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