Evidence map›Paper›PMID 40861952›Full record

ArticleRSC advances2025

Dynamic covalent interaction induced formation of a bortezomib-andrographolide complex and construction of the dual-drug delivery system.

Shihui Qiao, Hui Long, Yun Song, Xu Dong, Huamin Zhong, Huanfeng Meng, Jingwen Gong, Yong Wang, Yiheng Liu, Haiying Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shihui QiaoEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.
Hui LongEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.
Yun SongEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.
Xu DongEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.
Huamin ZhongEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.
Huanfeng MengEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.
Jingwen GongEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.
Yong WangEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.
Yiheng LiuAffiliated Haikou Hospital of Xiangya Medical College, Central South University P. R. China.
Haiying ZhangEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.
Lujia MaoEngineering Research Centre of Tropical Medicine Innovation and Transformation of Ministry of Education, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University (Hainan Academy of Medical Science) Haikou Hainan 571199 P. R. China maolujia@muhn.edu.cn.ORCID https://orcid.org/0000-0001-9080-2733

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interaction of boronic acids and 1,3-diols has significant application in tumour targeting and transcellular transfer, potentially to be employed in developing drug delivery systems. Bortezomib (BTZ), the dipeptide boronic acid analogue, is an FDA-approved anti-tumour drug. The hydrophobic boronic acid skeleton on BTZ resulted in unfavorable pharmacokinetic properties, which limits its efficacy for the treatment of solid tumours. Andrographolide (AND) holds significant potential for clinical application as a cancer treatment. The

Identifiers

PMID40861952
PMCPMC12377066

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.