Evidence map›Paper›PMID 40861921›Full record

ArticleCanada communicable disease report = Releve des maladies transmissibles au Canada2025

National hepatitis B and C estimates for 2021: Measuring Canada's progress towards eliminating viral hepatitis as a public health concern.

Simone Périnet, Anson Williams, Laurence Campeau, Janelle Elliott, Fan Zhang, Qiuying Yang, Joseph Cox, Karelyn Davis, Jordan J Feld, Marina B Klein and 4 more

Abstract read
In one paragraph

Article in Canada communicable disease report = Releve des maladies transmissibles au Canada, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Barriers to Hepatitis B Treatment: A Multicentre Cross-Sectional Registry and Survey Study by the Canadian Hepatitis B Network.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  2. A 40-year-old man with a new diagnosis of hepatitis B.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
  3. Article
  4. Estimating the population size of people who inject drugs in Canada, 2021.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025
    Review
  5. Estimated prevalence of hepatitis B and C among immigrants in Canada.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Simone PérinetCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Anson WilliamsCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Laurence CampeauCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Janelle ElliottCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Fan ZhangCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Qiuying YangCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Joseph CoxCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Karelyn DavisCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Jordan J FeldToronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, ON.
Marina B KleinResearch Institute of the McGill University Health Centre, Montréal, QC.
Nadine KronfliDepartment of Medicine, Division of Infectious Diseases and Chronic Viral Illness Service, McGill University, Montréal, QC.
Mia J BiondiSchool of Nursing, York University, Toronto, ON.
Peter K DaleyMemorial University of Newfoundland, St. John's, NL.
Nashira PopovicCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major causes of morbidity and mortality worldwide. Measuring the epidemiological burden of HCV and HBV in Canada is essential to measure progress towards global elimination targets and to ultimately eliminate viral hepatitis as a public health concern. Objective: This study aimed to provide the first national estimates of HBV prevalence and unawareness, and to update estimates of HCV incidence, prevalence, and unawareness in the general population and key populations in Canada for 2021. Progress towards elimination targets for 2025, namely incidence, awareness, mortality, and HBV vaccination, was also assessed. Methods: A combination workbook method and mathematical modelling was used to estimate the prevalence and unawareness of chronic hepatitis B (CHB), prevalence and incidence of anti-HCV antibodies, and the prevalence and unawareness of chronic hepatitis C (CHC). Results: The estimated prevalence of CHB was 0.68% (plausible range: 0.40%-0.97%) or 262,000 (152,000-371,000) people in the general population, of whom 42.5% (33.9%-51.0%) were unaware of their infection. Immigrants from countries where HBV is common had the highest prevalence at 4.2% (1.9%-5.6%). An estimated 8,212 new HCV infections occurred in 2021, and the estimated prevalence of CHC was 0.56% (0.15%-0.97%) or 214,000 (58,500-369,000) people, of whom 41.5% (34.3%-48.8%) were unaware of their infection. People who inject drugs had the highest prevalence and largest proportion who were unaware at 36.9% (12.6%-55.1%) and 49.9% (29.0%-70.2%), respectively. Conclusion: While the overall viral hepatitis burden is low in the general Canadian population, these estimates indicate that certain populations and communities remain disproportionately affected. Although Canada has met some of the 2025 targets, more work is needed. To this end, efforts to obtain and standardize provincial and national data will be required to measure progress towards all elimination targets.

Indexed as

Canadaestimationshepatitis Bhepatitis Cincidencekey populationsprevalenceviral hepatitis

Identifiers

PMID40861921
PMCPMC12372649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.