Evidence map›Paper›PMID 40861910›Full record

ReviewACS measurement science au2025

Comparative Roles of Hydrogels, Deep Eutectic Solvents, and Ionic Liquids in Enzyme-Based Biosensors, Bioelectronics and Biomimetics Devices.

Fhysmélia Firmino de Albuquerque, Rodrigo Michelin Iost, Frank Nelson Crespilho

Abstract readReview
In one paragraph

Review in ACS measurement science au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fhysmélia Firmino de AlbuquerqueSão Carlos Institute of Chemistry, University of São Paulo (USP), São Carlos 13560-970, Brazil.ORCID https://orcid.org/0000-0001-8897-187X
Rodrigo Michelin IostDepartment of Fundamental Chemistry, Institute of Chemistry, University of Sao Paulo, Av. Professor Lineu Prestes, 748-B4T, Butantã, Sao Paulo 05508-000, Brazil.ORCID https://orcid.org/0000-0003-2099-5052
Frank Nelson CrespilhoSão Carlos Institute of Chemistry, University of São Paulo (USP), São Carlos 13560-970, Brazil.ORCID https://orcid.org/0000-0003-4830-652X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of enzyme-based bioelectronic devices, including biosensors and biomimetic systems, has significantly advanced with the introduction of innovative materials such as hydrogels, deep eutectic solvents (DES), and ionic liquids (ILs). These materials offer unique advantages in enhancing biodevice performance, particularly in enzyme stabilization, biocompatibility, and electrochemical sensitivity. Hydrogels, known for their high water content and flexibility, provide an ideal matrix for enzyme immobilization in biological applications but are limited by low ionic conductivity. DES, with their green chemistry credentials and ability to stabilize enzymes under harsh conditions, show great promise, although scalability and performance in complex biological systems remain challenges. ILs, with their superior electron transfer capabilities, enable high sensitivity in electrochemical biosensors, though issues of viscosity and potential toxicity need to be addressed for broader biomedical use. This review provides a comparative analysis of the roles of these materials in enzyme-based biosensors and bioelectronics, including microbatteries and bioelectrosynthesis, highlighting their respective strengths, limitations, and future opportunities. The integration of these materials holds great potential for advancing bioelectronics technologies, with applications spanning medical diagnostics, environmental monitoring, and industrial processes. By addressing current challenges and optimizing these materials for large-scale use, the future of enzyme-based devices could see significant improvements in efficiency, sensitivity, and sustainability.

Indexed as

biocompatibilitybioinspired systemselectrochemical sensingenzyme immobilizationenzyme stabilizationfunctional materialshybrid biointerfacessoft materials

Identifiers

PMID40861910
PMCPMC12371592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.