ArticleFrontiers in bioengineering and biotechnology2025
Laminin-derived peptide drives the cardiomyogenic potential and cardiac cells functionality.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- ECM proteins regulate microRNA-mediated direct reprogramming of fibroblasts into cardiomyocytes via YAP signaling.Frontiers in bioengineering and biotechnology · 2026Article
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7 authors.
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Abstract
Laminin represents a major component of the basement membrane in cardiac tissue. Through integrins binding, laminin can sustain cell adhesion, proliferation, differentiation and mechanotransduction. The role of a small bioactive peptide (KKGSYNNIVVHV) derived from laminin in cardiac differentiation and functionality has been demonstrated. Briefly, results showed how the presence of laminin-derived peptide enhanced the differentiation of mesenchymal stem cells into cardiomyocytes-like phenotype, by modulating not only the cytoskeletal apparatus but also enhancing the cardiac and adhesion markers. Moreover, neonatal mouse cardiomyocytes in presence of the peptide showed well organized cytoskeletal rearrangements and regulated contractility. Therefore, in this study the role of laminin-derived peptide in guiding cardiomyogenesis has been characterized, opening innovative approaches in functional cardiac tissue engineering and regenerative medicine.
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