ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
The role of cognitive reserve in white matter hyperintensities: from cognitive aging to Alzheimer's spectrum.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Memory training through Chinese classics recitation for individuals with subjective cognitive decline: study protocol for a pilot study.Frontiers in aging neuroscience · 2026Article
- Cognitive Age Delta as a Marker of Healthy and Pathological Cognitive Aging: The Role of Lifestyle, Cognitive Reserve, and Vascular Risk.Journal of clinical medicine · 2025Article
- The role of cognitive reserve in white matter hyperintensities: from cognitive aging to Alzheimer's spectrum.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
3 authors.
Funding
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Abstract
introductionWhite matter hyperintensities (WMHs) are characteristic of Alzheimer's disease (AD), and cognitive reserve (CR) protects cognitive function. However, whether WMHs mediate the CR-cognition relationship remains unclear.
methodsBrain imaging, clinical features, and neuropsychological assessments were performed, and CR was measured using the Cognitive Reserve Index questionnaire. Bootstrap mediation analysis examined CR's role in specific cognitive functions, controlling for covariates.
resultsParticipants who were cognitively unimpaired (CU; DISCUSSION: CR may maintain the optimal cognitive function by mitigating the WMH burden independently of AD-related brain changes. Highlights: Cognitive reserve (CR) positively links to non-memory cognition.Cognitive reserve mitigates white matter hyperintensities to preserve cognition.Cognitive reserve primarily protects cognition in pre-Alzheimer's stages.
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Registered trials
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