ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Relationships among young adult general cognitive ability, midlife physical activity, and early late-life cognitive functioning: A four-decade longitudinal cohort study in men.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Prospective study on physical activity and Alzheimer's disease-related biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Data-driven leisure-time physical activity trajectories of over 46 years and their associations with cognition in nonagenarians: a cohort study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Relationships among young adult general cognitive ability, midlife physical activity, and early late-life cognitive functioning: A four-decade longitudinal cohort study in men.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
introductionResearch on whether physical activity (PA) is associated with cognition is abundant but very few studies have examined the extent to which prior cognitive ability may account for PA participation in midlife.
methodsOver 800 men self-reported PA at average ages of 40 and 56. General cognitive ability (GCA) was assessed at an average age of 20. Specific cognitive abilities and GCA were assessed at average ages of 56 and 68. Relationships among age 20 GCA, midlife PA, and cognitive functioning in mid- and late-life were examined with generalized estimating equations.
resultsAge 20 GCA was significantly associated with age 56 leisure metabolic equivalent of energy expenditure (MET)-hours of PA ( DISCUSSION: There are reciprocal associations between PA and cognitive functioning. Highlights: Young adult general cognitive ability (GCA) predicts midlife physical activity (PA).Midlife PA and cognition were not associated after adjusting for young adult GCA.Midlife PA is associated with later-life cognition, adjusted for young adult GCA.Work-related PA was inversely associated with later-life cognitive functioning.The relationship between PA and cognitive function is bidirectional.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.