Evidence map›Paper›PMID 40861824›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Proteomic profiling identifies serpin G1, ApoA-II, and LBP as potential biomarkers of dementia in an Egyptian cohort.

Shimaa A Heikal, Eman M Khedr, Mai Othman, Nesma G Elsheikh, Heba M Tawfik, Hany I Hassanin, Nouran Al-Shehaby, Ashraf Eltaher, Samir Shamma, Ahmed S Mohamed and 8 more

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Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shimaa A HeikalInstitute of Global Health and Human Ecology The American University in Cairo Cairo Egypt.
Eman M KhedrNeuropsychiatry Department Assiut University Assiut Egypt.
Mai OthmanInstitute of Global Health and Human Ecology The American University in Cairo Cairo Egypt.
Nesma G ElsheikhGeriatric Medicine Department, Faculty of Medicine Ain Shams University Cairo Egypt.
Heba M TawfikGeriatric Medicine Department, Faculty of Medicine Ain Shams University Cairo Egypt.
Hany I HassaninGeriatric Medicine Department, Faculty of Medicine Ain Shams University Cairo Egypt.
Nouran Al-ShehabyResearch Department Tumor Biology Research Program, Basic Research Unit Children's Cancer Hospital Egypt Cairo Egypt.
Ashraf EltaherResearch Department Tumor Biology Research Program, Basic Research Unit Children's Cancer Hospital Egypt Cairo Egypt.
Samir ShammaInstitute of Global Health and Human Ecology The American University in Cairo Cairo Egypt.
Ahmed S MohamedNeuropsychiatry Department Aswan University Aswan Egypt.
Mostafa SaberNeuropsychiatry Department Aswan University Aswan Egypt.
Abdullah A LomombaNeuropsychiatry Department Aswan University Aswan Egypt.
Esraa AliNeuropsychiatry Department Assiut University Assiut Egypt.
Shady M SafwatNeuropsychiatry Department Assiut University Assiut Egypt.
Noha Abo ElfetohNeuropsychiatry Department Assiut University Assiut Egypt.
Gharib FawiNeurology Department, Faculty of Medicine Sohag University Sohag Egypt.
Noha A YousriComputer and Systems Engineering, Faculty of Engineering, Alexandria University Alexandria Egypt.
Mohamed SalamaInstitute of Global Health and Human Ecology The American University in Cairo Cairo Egypt.ORCID https://orcid.org/0000-0003-1644-0273

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDementia, including Alzheimer's disease (AD), is a growing concern in Egypt, yet biomarker research in this population is scarce. Identifying serum biomarkers is essential for early diagnosis and understanding disease mechanisms in underrepresented groups.

methodsWe performed serum proteomic profiling on 20 Egyptian dementia patients and 10 cognitively unimpaired controls from the Egyptian Dementia Registry using mass spectrometry. Differential protein expression and pathway enrichment analyses were conducted.

resultsOf 260 quantified proteins, 21 were significantly different between dementia patients and controls (

conclusionThis is the first serum proteomic study of dementia in an Egyptian cohort, highlighting coordinated changes in protein families involved in inflammation and lipid metabolism, and emphasizing the importance of biomarker research in diverse populations. Highlights: The study presents initial proteomic data from the Egyptian Dementia Registry.The Egyptian population has been underrepresented in the area of dementia research.Serine protease inhibitor G1, apolipoprotein A-II, and lipopolysaccharide binding protein emerged as significant proteins.The work lays the foundation for more understanding of molecular determinants in dementia in the Middle East.

Indexed as

Alzheimer's diseasebiomarkersdementiaEgyptproteomic profilingunderrepresented population

Identifiers

PMID40861824
PMCPMC12375432

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.