ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Accounting for white matter uptake improves between tracer agreement in amyloid PET.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Accounting for white matter uptake improves between tracer agreement in amyloid PET.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
introductionAmyloid positron emission tomography (PET) allows in vivo measurement of amyloid plaque deposition; however, different tracers lead to different results. We test the hypothesis that the variability in amyloid measurements is related to white matter retention, and accounting for this variability can improve agreements.
methodsData from the Centiloid project was downloaded and processed for four F18 tracer-to-Pittsburgh Compound B (PiB) pairs to obtain mean cortical standardized uptake value ratio (MCSUVR). Three approaches were examined to account for white matter contribution to the MCSUVR. Pearson's correlation was used to assess the between tracer agreements. Steiger's test was used to determine the significance of improvement.
resultsAccounting for white matter signal improves the agreement. The regional spread function partial volume correction (RSF PVC) method was most consistent in achieving statistically significant improvements ( DISCUSSION: Between-tracer agreement of amyloid measure can be improved by accounting for white matter signal. Further investigation is ongoing for additional improvement. Highlights: Analyzing head-to-head data for all four common F18-labeled tracers against Pittsburgh Compound B (PiB).Evaluating three different techniques to correct for white matter signal.Steiger's test to determine the significance of improvements.White matter uptake contributes to the between-tracer measurement difference.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.