ArticleJournal of circulating biomarkers
Monocyte Distribution Width (MDW) as a useful and cost-effective biomarker for sepsis prediction.
Article in Journal of circulating biomarkers. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Diagnostic accuracy and severity prediction of monocyte distribution width in sepsis: a retrospective study from the United Arab Emirates.Frontiers in medicine · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sepsis is a life-threatening condition and a major cause of hospital mortality worldwide. This study investigated the diagnostic utility of monocyte mean volume (MONO MEAN-V), monocyte distribution width (MDW), monocyte mean conductivity (MONO MEAN-C), and monocyte standard deviation conductivity (MONO Sd-C) for sepsis, compared to conventional markers. Methods: A prospective cohort study was conducted in two centers, enrolling adult patients classified into three groups: sepsis, septic shock, and febrile. Blood was drawn from septic patients on days 1, 3, and 5 of admission. MDW and other inflammatory parameters were measured in all patients. Results: Patients with sepsis or septic shock exhibited significantly elevated MONO MEAN-V, MDW, and MONO MEAN-C and lower MONO Sd-C compared to febrile patients. Among the biomarkers evaluated, MDW emerged as a reliable predictor of sepsis. A cut-off MDW value of 25.1 on day 1 demonstrated optimal diagnostic performance, with an area under the ROC curve of 0.84 (95% CI: 0.77-0.91), sensitivity of 75%, and specificity of 91.2%. Conclusions: MDW appears to be a cost-effective, rapid marker for sepsis detection, performing at least as effectively as existing biomarkers. Our findings corroborate other published studies, highlighting MDW's potential to enhance early sepsis recognition.
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