ArticleCureus2025
Primary Extraosseous Ewing Sarcoma of the Vulva: Unravelling the Mystery of a Common Tumor in an Uncommon Site.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Primary pelvic extraskeletal Ewing sarcoma: a case report and comprehensive literature review of molecularly confirmed cases arising within the female genital tract.Gynecologic oncology reports · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary vulvar Ewing sarcoma (ES) is exceedingly rare, particularly in postmenopausal women. To date, only 14 cases have been confirmed through molecular cytogenetic analysis. We report the case of a 55-year-old woman presenting with a painful, ulcerated vulvar mass. Imaging revealed a 6×7.9×8.5 cm lobulated soft tissue lesion. Contrast-enhanced computed tomography (CECT) demonstrated pulmonary metastases. Histopathology of the vulvar mass showed sheets of malignant small round cells, which were highlighted by strong membranous CD99 expression and NKX2.2 nuclear expression on immunohistochemistry. Fluorescence in situ hybridization (FISH) using a break-apart probe confirmed EWSR1 gene rearrangement, establishing the diagnosis of ES. Despite receiving eight cycles of chemotherapy, the patient succumbed to the disease. This is the 15th reported case of primary vulvar ES with molecular confirmation. The case highlights the importance of considering ES in the differential diagnosis of vulvar tumors and underscores the value of molecular diagnostics in guiding management.
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Registered trials
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