ReviewCureus2025
Association Between Magnesium Levels and Periodontal Disease: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Magnesium and blood pressure regulation: systemic and renal mechanisms.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Evaluation of serum chromium, nickel, and magnesium levels in patients with type 2 diabetes mellitus and periodontitis: A cross-sectional study.Clinical oral investigations · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease, a persistent inflammatory disorder that damages tissues supporting the teeth, is mainly triggered by an imbalanced microbial biofilm and an overactive immune-inflammatory reaction. Recent studies underscore the possible contribution of micronutrient shortages, especially in magnesium, in the progression of periodontitis. This systematic review synthesizes evidence on the association between magnesium levels, the magnesium/calcium (Mg/Ca) ratio, and periodontal disease, focusing on blood-based measures and dietary intake. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched PubMed, Cochrane Library, and Google Scholar from inception to May 2024, including 10 observational and experimental studies in adults. Narrative synthesis revealed consistent inverse associations: higher magnesium levels correlated with reduced probing pocket depth, clinical attachment loss, and periodontitis prevalence, while favorable Mg/Ca ratios protected against progression (e.g., odds ratio of 6.28 for low ratios). Systemic associations, particularly with diabetes, showed lower magnesium in comorbid cases, with post-treatment improvements suggesting anti-inflammatory benefits. Heterogeneity precluded meta-analysis. These findings highlight the protective role of magnesium, warranting large-scale trials to guide supplementation and dietary strategies for periodontal management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.