ReviewCureus2025
Genetic and Behavioral Predictors of Long-Term Weight Loss Maintenance: A Systematic Review of Evidence From Observational and Genetic Studies.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Lifestyle Adherence and Metabolic Control in Adults with Type 2 Diabetes: Development of a Lifestyle Compliance Index.Diagnostics (Basel, Switzerland) · 2026Article
- Perceived Competence and GLP-1RA Weight Management Engagement: Mixed-Methods Insights From Six Patient Groups.Obesity (Silver Spring, Md.) · 2026Article
- Article
- Perceptions, attitudes, and experiences of GLP-1 receptor agonists for weight management in the United Kingdom: a cross-sectional survey study.BMC public health · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term weight loss maintenance remains a significant challenge in obesity management, despite advances in behavioral, dietary, and medical interventions. The objective of this study is to identify consistent genetic and behavioral predictors associated with sustained weight loss in adults with overweight or obesity.
methodsWe searched PubMed, Embase, PsycINFO, Web of Science, and Google Scholar for peer-reviewed studies published from January 2010 to April 2025. Eligible studies included observational and genetic investigations involving adults who maintained at least 10% weight loss for one year or more. Quality was assessed using the Newcastle-Ottawa Scale (NOS) and genetic validity criteria. A thematic synthesis categorized predictors as behavioral or genetic.
results24 studies met the inclusion criteria (15 observational, nine genetic). Consistent behavioral predictors included increased physical activity, dietary restraint, low disinhibition, and improved psychological health. Genetically, FTO risk alleles and higher polygenic risk scores were associated with weight regain; however, structured behavioral interventions mitigated this effect. Specific gene variants (e.g., PPARγ, TIMP4) were linked to enhanced weight loss outcomes in response to multidisciplinary interventions.
conclusionBoth genetic and behavioral factors independently and interactively influence long-term weight loss maintenance. Integrating genetic risk profiling with personalized behavioral strategies may improve obesity treatment outcomes.
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Registered trials
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