ArticleCureus2025
Sporadic Fundic Gland Polyposis Associated With Long-Term Proton Pump Inhibitor Use: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fundic gland polyps (FGPs) are the most common type of gastric polyps and are frequently discovered incidentally during upper endoscopy. Long-term use of proton pump inhibitors (PPIs) has been associated with an increased risk of developing FGPs. We present a case of PPI-induced FGP in a 78-year-old woman who had been taking omeprazole daily for 15 years and was referred for evaluation of anemia. Gastroscopy revealed innumerable FGPs in the gastric body. Histological analysis demonstrated dilated glands within the fundic mucosa, consistent with FGPs. These polyps are typically small and benign and located in the gastric corpus and fundus. While FGPs are generally non-neoplastic, discontinuation of PPI therapy should be considered on a case-by-case basis. Indications for long-term PPI use should be regularly assessed. Unnecessary PPI therapy should be discontinued when appropriate.
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