ArticleCureus2025
An Adult-Onset Case of Porokeratotic Eccrine Ostial and Dermal Duct Nevus (PEODDN) in a Previously Healthy 28-Year-Old Indian Male: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 28-year-old Indian male with no previous medical or dermatological history presented with mildly pruritic linear skin lesions over the right anterior chest and arm. The lesions had been gradually progressing over the course of six years. Examination revealed multiple confluent, reddish-brown papules following Blaschko's lines, along with punctate hyperkeratotic papules over the right hand, with sparing of the mucosa, scalp, and nails. Histopathological analysis demonstrated a cup-shaped epidermal invagination filled with a parakeratotic column, absence of the granular layer, and dyskeratotic keratinocytes, with an eccrine duct located at the base of the lesion - indicating an acrosyringial origin. These findings confirmed the diagnosis of porokeratotic eccrine ostial and dermal duct nevus (PEODDN). PEODDN is a rare hamartomatous disorder with eccrine differentiation. While it usually presents at birth or during childhood, adult-onset cases have been documented - particularly along Blaschko's lines. The condition may present with porokeratotic plaques or comedo-like plugs on acral sites, and our case uniquely exhibited both features. Although its pathogenesis remains unclear, several theories suggest abnormal keratinization, structural defects in eccrine ducts, and possible genetic mutations. PEODDN may occasionally be associated with systemic or neoplastic conditions. Treatment options remain variable, and while no standard therapy offers complete resolution, our findings support the potential role of oral retinoids in improving lesion appearance and symptoms in adult-onset cases. Further evaluation of systemic retinoid therapy in PEODDN is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.