Evidence map›Paper›PMID 40861490›Full record

ArticleFrontiers in cellular and infection microbiology2025

Effects of oral gavage with periodontal pathogens and plaque biofilm on gut microbiota ecology and intestinal tissue architecture in mice: a mechanistic study.

Lan Huang, Song Ge, Kun Yang, Lian Duan, Li Gao, Yu Zhen Li, Yu Shi Yi

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Journal of oral microbiology · 2026
    Article
  4. Review
  5. Review
  6. Cyclodextran preventsFrontiers in oral health · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lan HuangPeriodontal Department, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
Song GePeriodontal Department, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
Kun YangPeriodontal Department, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
Lian DuanPeriodontal Department, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
Li GaoPeriodontal Department, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
Yu Zhen LiPeriodontal Department, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
Yu Shi YiPeriodontal Department, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to establish an Methods: Fifty 7-week-old male C57BL/6 mice were randomized into five groups(n=10/group): control (H), Results: A stable Conclusion: These findings demonstrate that periodontal pathogens induce gut barrier compromise through microbiome-driven immunomodulation, with

Indexed as

BiofilmsDental PlaqueGastrointestinal MicrobiomeAnimalsBacteriaColonCytokinesDisease Models, AnimalDysbiosisFecesFusobacterium nucleatumMaleMiceMice, Inbred C57BLPorphyromonas gingivalisRNA, Ribosomal, 16SCytokinesRNA, Ribosomal, 16S16S rRNA sequencingdysbiosisFusobacterium nucleatumoral-gut axisPorphyromonas gingivalisStreptococcus sanguinistight junctions

Identifiers

PMID40861490
PMCPMC12370644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.