Evidence map›Paper›PMID 40861464›Full record

ReviewFrontiers in immunology2025

The interaction between common genetic mutations in AML and the immune landscape: mechanisms and implications for immune response.

Xuege Guo, Hanlu Zhang, Xiao Wang, Lijuan Li, Liansheng Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xuege GuoDepartment of Hematology, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.
Hanlu ZhangDepartment of Hematology, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.
Xiao WangDepartment of Hematology, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.
Lijuan LiDepartment of Hematology, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.
Liansheng ZhangDepartment of Hematology, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy driven by diverse genetic mutations that shape tumor progression, immune evasion, and clinical outcomes. While molecular profiling has improved AML classification, the precise impact of specific mutations on immune cell infiltration and dysregulation remains insufficiently understood. This review examines the immunologic consequences of common AML mutations-including

Indexed as

Leukemia, Myeloid, AcuteMutationAnimalsHumansImmunotherapyNucleophosminTumor EscapeTumor MicroenvironmentNPM1 protein, humanNucleophosminacute myeloid leukemiagene mutationimmune microenvironmentimmunotherapyneoepitopesrisk stratification

Identifiers

PMID40861464
PMCPMC12375677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.