Evidence map›Paper›PMID 40861411›Full record

ArticleEuropean heart journal. Case reports2025

Treatment of impending paradoxical embolism with systemic thrombolysis and cerebral embolic protection: a case report.

Erika Tempo, Edoardo Bertero, Gabriele Crimi, Matteo Vercellino, Italo Porto

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erika TempoDepartment of Internal Medicine (Di.M.I.), Chair of Cardiovascular Disease, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy.ORCID https://orcid.org/0009-0001-3151-2709
Edoardo BerteroCardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132  Genoa, Italy.ORCID https://orcid.org/0000-0002-3175-8151
Gabriele CrimiCardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132  Genoa, Italy.ORCID https://orcid.org/0000-0002-2852-061X
Matteo VercellinoCardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132  Genoa, Italy.
Italo PortoDepartment of Internal Medicine (Di.M.I.), Chair of Cardiovascular Disease, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy.ORCID https://orcid.org/0000-0002-9854-5046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Impending paradoxical embolism is a rare and life-threatening occurrence and evidence guiding its optimal management is lacking. Case presentation: A 73-year-old man presenting with ST-elevation myocardial infarction was diagnosed with impending paradoxical embolism, as a large thrombus was visualized entrapped in a patent foramen ovale. We performed systemic thrombolysis after deployment of a cerebral protection device, which resulted in complete dissolution of the thrombus without major thromboembolic events. Thrombolysis was complicated by development of intracranial haemorrhage that resolved without major neurological sequelae. The patient was discharged on a direct oral anticoagulant. Discussion: Treatment strategies for impending paradoxical embolism include surgical thrombectomy, percutaneous thrombus retrieval, and systemic thrombolysis. We report for the first time the effective use of a cerebral embolic protection device to reduce the risk of ischaemic injury to the brain during systemic thrombolysis.

Indexed as

Case reportCerebral embolic protectionImpending paradoxical embolismSystemic thrombolysis

Identifiers

PMID40861411
PMCPMC12374158

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