Evidence map›Paper›PMID 40861386›Full record

ArticleJournal of Alzheimer's disease reports

Association of cardiovascular disease with dementia: A longitudinal analysis using National Alzheimer's Coordinating Center data.

Diana Summanwar, Hyena Kim, Jingkai Wei, Malaz Boustani, Alvaro Alonso, Ambar Kulshreshtha

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Diana SummanwarDepartment of Family Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0002-7529-3632
Hyena KimDepartment of Family and Preventive Medicine, Emory University, Atlanta, GA, USA.ORCID https://orcid.org/0009-0007-0428-7554
Jingkai WeiDepartment of Family and Community Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID https://orcid.org/0000-0001-8941-8662
Malaz BoustaniDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0003-0330-677X
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID https://orcid.org/0000-0002-2225-8323
Ambar KulshreshthaDepartment of Family and Preventive Medicine, Emory University, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-4610-1352

Funding

The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
NIA NIH HHS P30 AG066511
6 · The paper itself

Abstract

We analyzed how cardiovascular disease subtypes influence the prevalence and incidence of dementia among 30,582 individuals aged 50 and older in the National Alzheimer's Coordinating Center cohort. We calculated prevalence ratios (aPR) and hazard ratios (aHR), using models adjusted for age, sex, race, years of education, hypertension, diabetes, and dyslipidemia. Stroke (aPR: 1.26; 95% CI: 1.20-1.32) and history of arrhythmias (aPR: 1.17; 95% CI: 1.09-1.24) were associated with higher dementia prevalence. In survival analysis, stroke was associated with a 55% increased risk of incident dementia (aHR: 1.55; 95% CI: 1.36-1.77).

Indexed as

Alzheimer's diseasecardiovascular diseasescardiovascular risk factorscognitive dysfunctiondementiaepidemiologyincidencelongitudinal studiespreventionstroke

Identifiers

PMID40861386
PMCPMC12371225

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.