Evidence map›Paper›PMID 40861380›Full record

ArticleGenomic psychiatry : advancing science from genes to society2025

Recent findings and future directions for the intersection of genetic and environmental contributions to schizophrenia.

Natassia Robinson, Sarah E Bergen

Abstract read
In one paragraph

Article in Genomic psychiatry : advancing science from genes to society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Natassia RobinsonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0001-8408-101X
Sarah E BergenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0002-5888-0034

Funding

A comparison of environmental and genetic risks for schizophrenia and bipolar disorder: A Swedish national studyR01MH122544 · NIMH · KAROLINSKA INSTITUTE · PI BERGEN, SARAH E · 2020 to 2023
$1.2M
NIMH NIH HHS R01 MH122544
6 · The paper itself

Abstract

It is well established that both genetic and environmental factors contribute to risk for schizophrenia (SCZ), and much progress has been made in identifying the specific factors conferring risk. However, the nature and extent of interactions between them has long been a topic of debate. Both the data and methods available to address this have evolved rapidly, enabling new prospects for identifying gene-environment interactions in SCZ. To date, there is limited evidence of strong gene-environment interactions, with environmental factors, molecular genetic risk, and family history simultaneously contributing to risk of SCZ. Still, there are several enduring challenges, some of which can likely be addressed with new tools, methods, and approaches for investigating gene-environment interplay. Consequently, advancements in this field will enhance our capacity to identify individuals most vulnerable to specific environmental exposures, which is pivotal for targeted prevention and intervention.

Indexed as

gene environment interactiongenetic risk scorerisk factorsSchizophrenia

Identifiers

PMID40861380
PMCPMC12377634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.