Evidence map›Paper›PMID 40861317›Full record

ArticleTherapeutic advances in medical oncology2025

Dialysis dependence is associated with poor prognosis in multiple myeloma: a multicenter retrospective cohort study.

Ji-Nuo Wang, Chenyun Wang, Jinping Ying, Gaofeng Zheng, Xiaoyan Han, Peng An, Gang Wang, Fei Chen, Li Yang, Yang Yang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in medical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Ji-Nuo WangBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0003-4036-7547
Chenyun WangBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jinping YingDepartment of Nephrology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Gaofeng ZhengBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, China.
Xiaoyan HanBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, China.
Peng AnDepartment of Hematology, Anji People's Hospital, Huzhou, Zhejiang, China.
Gang WangDepartment of Hematology, Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, Zhejiang, China.
Fei ChenDepartment of Hematology, Haining People's Hospital, Jiaxing, Zhejiang, China.
Li YangBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, China.
Yang YangBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, China.
Donghua HeBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, China.
Jingsong HeBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, China.
Yuanshuai ChenArtificial Intelligence and Information, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Wenjun WuBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaInstitute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.
Zhen CaiBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaInstitute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with multiple myeloma (MM) and renal impairment (RI), particularly those requiring dialysis, have historically experienced poor outcomes. Despite advancements in targeted therapies, the prognosis of dialysis-dependent MM and factors influencing dialysis independence remain unclear. Objectives: This study aimed to provide a comprehensive analysis of the clinical manifestations and treatment outcomes of dialysis-dependent MM patients in China, and to explore the factors associated with dialysis independence and long-term survival. Design: We conducted a multicenter, retrospective, real-world cohort study. Methods: This multicenter, retrospective study included 122 MM patients requiring chronic hemodialysis (⩾28 days of treatment) at 4 comprehensive hospitals in China from January 2012 to November 2023. Hemodialysis resulting from causes other than MM was excluded. Logistic regression was employed for multivariate analysis of factors associated with dialysis independence, and Kaplan-Meier survival curves and Cox proportional hazard models were utilized for survival analysis. Results: Among the 122 patients, 74 patients (60.7%) were male, with a median age of 65 (39-87) years. Of these, 71.3% ( Conclusion: In the era of new drugs, dialysis-dependent MM still has a poor prognosis, although dialysis independence improves survival.

Indexed as

dialysisdialysis independencemultiple myelomarenal impairmentsurvival

Identifiers

PMID40861317
PMCPMC12374089

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