Evidence map›Paper›PMID 40861299›Full record

ArticleRSC advances2025

Synergistic chemotherapy and phototherapy co-delivery nanoparticle preparation and anti-triple negative breast cancer study.

Fan Yang, Hongchi Liu, Qian Luo, Hao Deng, Rongrong Zhang, Yi Yang, Hong Yang, Huaying Wu, Xiaojun Tao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fan YangKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University Changsha 410013 China HuayingWu6@hunnu.edu.cn taoxiaojun1981@outlook.com.
Hongchi LiuKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University Changsha 410013 China HuayingWu6@hunnu.edu.cn taoxiaojun1981@outlook.com.
Qian LuoDepartment of Oncology, Hunan Normal University First Affiliated Hospital Hunan Provincial People's Hospital Changsha 410005 China.ORCID https://orcid.org/0000-0002-3054-8101
Hao DengKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University Changsha 410013 China HuayingWu6@hunnu.edu.cn taoxiaojun1981@outlook.com.
Rongrong ZhangKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University Changsha 410013 China HuayingWu6@hunnu.edu.cn taoxiaojun1981@outlook.com.
Yi YangKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University Changsha 410013 China HuayingWu6@hunnu.edu.cn taoxiaojun1981@outlook.com.
Hong YangDepartment of Oncology, Hunan Normal University First Affiliated Hospital Hunan Provincial People's Hospital Changsha 410005 China.
Huaying WuKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University Changsha 410013 China HuayingWu6@hunnu.edu.cn taoxiaojun1981@outlook.com.
Xiaojun TaoKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University Changsha 410013 China HuayingWu6@hunnu.edu.cn taoxiaojun1981@outlook.com.ORCID https://orcid.org/0000-0002-3451-9850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, the amphiphilic polymer HA-ANI, formed by grafting hyaluronic acid (HA) and 6-(2-nitroimidazolyl)hexylamine (ANI), was self-assembled in water to form nanoparticles (NPs), which were modified to obtain dual drug-loaded nanoparticles (P/I NPs) by dialysis loading of paclitaxel (PTX) and IR780. Electron microscopy and dynamic light scattering (DLS) results showed that the P/I NPs presented a near-spherical shape with a size of 221.10 ± 2.31 nm. The drug loading and encapsulation rates of PTX in P/I NPs were 22.73% and 89.23%, respectively, and those of IR780 were 1.11% and 42.44%, respectively.

Identifiers

PMID40861299
PMCPMC12377245

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.