ArticleJournal of translational internal medicine2025
Is integrative therapy of traditional Chinese medicine and progesterone capsule more effective than monotherapies in oligomenorrhea and hypomenorrhea? Evidence based on a multi-center randomized controlled trial and metabolomic profile.
Article in Journal of translational internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Oligomenorrhea and hypomenorrhea were common conditions in outpatient visit which affected child-bearing aged women, and the conventional progesterone treatment has been related to several side effect and contradiction, and this study aimed to evaluate the effectiveness and safety of traditional Chinese medicine (TCM), progesterone capsules, and their combination in treating oligomenorrhea and hypomenorrhea Methods: A prospective, randomized, multi-center trial has been conducted, and a total of 239 oligomenorrhea and hypomenorrhea were randomly assigned to receive TCM, progesterone capsules (PG), or the combined Chinese and Western medicine (COM) and treated from 3 months, respectively. Scores were recorded at 1 Results: A total of 220 participants completed the trial treatment, with dropout rate of 11.6%. The Traditional Chinese Medicine Syndrome Scale (TCMSS) scores of each group were significantly lower than those before treatment after 1 month of treatment and after 3 months of treatment. After 3 months of treatment, the COM group had the highest total effective rate (61.54%). The pictorial blood loss assessment chart (PBAC) scores in the TCM group were significantly higher than those before treatment after 1 month of treatment and 3 months after treatment, whereas no difference before and after treatment was observed within PG group. In COM group, the score after 3 months of treatment was significantly higher than that before treatment. In the post-hoc study with metabolomic approach with KEGG pathway enrichment and topological analyses, glycerophospholipid (GPL) metabolism were found significantly altered in all 3 groups. while TCM could potentially improve the clinical symptom Conclusion: From the perspective of TCMSS scores, the effect of COM group is more significant. In terms of PBAC scores, sex hormone level, endometrium and the improvement of ovarian function in patients with low ovarian function, the TCM group had a better response. In a comprehensive evaluation, the regimen of TCM alone or COM can significantly improve menstrual flow and treat oligomenorrhea and hypomenorrhea patients. With KEGG pathway enrichment and topological analyses, GPL metabolism were found significantly altered in all 3 groups, and TCM could potentially improve the clinical symptom
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.