ArticleJournal of translational internal medicine2025
NETosis and pyroptosis of immune cells in sepsis.
Article in Journal of translational internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Multi-targeted biomimetic CeO₂-based nanoplatform for sepsis therapy via mitochondrial homeostasis.International journal of pharmaceutics: X · 2026Article
- Engineered hollow Prussian blue nanoparticles for synergistic anti-inflammatory therapy in sepsis.Materials today. Bio · 2026Article
- Admission CRP as an Independent Predictor of Prolonged Length of Stay in Calculous Acute Pyelonephritis: A Comparative Evaluation With the HALP Score.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Heterogeneity of Immunological, Coagulation and Complement Clustering to Viral Challenge and Clinical Relevance.International journal of molecular sciences · 2026Article
- Emerging Nanomedicine Strategies for Sepsis: Immunomodulation and Beyond.Research (Washington, D.C.) · 2026Article
- Neutrophil extracellular traps in atherosclerosis: current evidence and therapeutic potential of plant-derived metabolites.Frontiers in pharmacology · 2026Review
- Potential mitochondria-associated pathogenic genes in sepsis: a multi-omics Mendelian randomization study.Frontiers in immunology · 2026Article
- Regulated Cell Death Pathways in Chondrocytes During Septic Arthritis: Current Evidence and Future Perspectives.Journal of inflammation research · 2026Review
- Immune monitoring, immune phenotyping, and precision intervention in severe pneumonia: current evidence and translational challenges.Frontiers in immunology · 2026Review
- Peripheral immune phenotyping identifies an immunosuppressed sepsis endotype with potential relevance for immune stratification.Frontiers in immunology · 2026Article
- Cuproptosis in Sepsis: Cell Type-Specific Mechanisms and Clinical Prospects.Drug design, development and therapy · 2026Review
- Cell death in sepsis: unveiling new perspectives on organ dysfunction.Frontiers in cell and developmental biology · 2026Review
- Unfractionated heparin improves coagulation in sepsis by protecting glycocalyx of endothelia cells through inhibiting heparinase.Journal of translational internal medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis, a potentially fatal illness marked by an abnormal host immune response to an infection, continues to be a major global health issue. This study explores the role of pyroptosis and neutrophil extracellular traps (NETs) and their complex interactions, two dominant immune cell death, in the setting of sepsis. The review begins by explaining sepsis and its strong dependence on the immune system. It then delves into the basic mechanisms of neutrophil extracellular trap associated death (NETosis) and pyroptosis, examining their functions in inflammation and host defense. Going further, it looks at the dysregulated immune response in sepsis, with a focus on neutrophils and other immune cells and their critical role. We analyze in detail two types of cell death: pyroptosis and NETosis, both of which are closely examined for their roles in the development of sepsis, particularly the escalation of pathophysiology. Additionally, the study looks into the complex interactions between pyroptosis and NETosis, illuminating possible mechanisms for control as well as their cooperative effects. The report concludes with a summary of the major findings and recommendations for future therapy approaches and research prospects. This review adds to our knowledge of the pathophysiology of sepsis by thoroughly analyzing the roles of NETosis and pyroptosis in sepsis and providing possible directions for therapeutic intervention.
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