ArticleFrontiers in neurology2025
Passive head-up tilt positioning as an early mobilization strategy in neurocritical care: a prospective-retrospective controlled study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Safety of Protocolized Motorized Verticalization in Critically Ill Patients With Impaired Consciousness and Invasive Devices, Including External Ventricular Drains.Critical care explorations · 2026Article
- Effect of Vestibular Stimulation Exercises on Level of Consciousness in Patients With Intracerebral Hemorrhage.Cureus · 2026Article
- Frequency of physical and occupational therapy in the ICU for patients with cognitive motor dissociation: a retrospective cohort study.Critical care (London, England) · 2025Article
- A prospective observational study of head-of-bed adjustment for patients following elective craniotomy based on cerebral autoregulation.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Background: Early mobilization is recommended in neurocritical care, yet passive mobilization strategies for patients with impaired consciousness remain underexplored. This retrospective matched cohort study, incorporating prospectively collected intervention data, evaluates the clinical efficacy and physiological impact of passive head-up tilt positioning in patients with severe neurological injury. Methods: We conducted a prospective-retrospective matched cohort study involving 58 patients with traumatic brain injury or hypertensive intracerebral hemorrhage. Twenty-nine patients received standardized passive verticalization using a motorized standing bed; 29 matched controls received standard care. Intracranial dynamics (ICP, CPP, and PRx), respiratory mechanics, intra-abdominal pressure (IAP), and neurological assessments (GCS, CRS-R, ICDSC) were measured at defined intervals. Primary outcomes included NSICU/hospital length of stay, duration of ventilation, complication rates, and long-term functional outcomes. Results: Passive verticalization was well-tolerated and associated with a significant reduction in ICP (10.62 ± 2.13 vs. 8.38 ± 2.27 mmHg, Conclusion: Passive head-up tilt positioning is a safe, feasible early mobilization strategy in neurocritical care. It improves neurological recovery, reduces complications, and supports long-term functional outcomes. These findings support the incorporation of passive verticalization into early rehabilitation protocols for patients unable to engage in active mobilization.
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