ArticleAesthetic surgery journal. Open forum2025
A Randomized Clinical Trial Comparing Pure Hyaluronic Acid to the Hyaluronic Acid-Calcium Hydroxylapatite Combination for Temporal Volumization.
Article in Aesthetic surgery journal. Open forum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) are commonly used for facial volumization, with HA offering hydration and reversibility, whereas CaHA provides structural support and collagen biostimulation. Recently, a combination of HA and CaHA has been proposed to enhance both immediate volumization and long-term tissue remodeling. However, its efficacy for volume retention remains unclear. Objectives: In this study, the authors aim to compare the volumetric retention and clinical outcomes of HA alone vs a manually prepared HA-CaHA mixture in the temporal region over a 90-day follow-up. Methods: A randomized controlled trial included 20 patients (40 hemifaces) treated with either 0.5 mL of HA alone (G1) or a 40% HA and 60% CaHA mixture (G2). Fillers were injected subcutaneously using a 22 G cannula with a fan technique. Volumetric changes were assessed through 3-dimensional stereophotogrammetry, and the Allergan Temple Scale (ATS) evaluated qualitative outcomes. Results: Both groups showed significant ATS score improvements over time ( Conclusions: The hypothesized synergy of the HA-CaHA combination was not observed. HA alone provided superior long-term volumization, suggesting that manual HA-CaHA mixing may alter filler performance. Further studies should explore premixed formulations and optimize treatment protocols. Level of Evidence 2 Therapeutic:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.