ArticleJournal of inflammation research2025
Identification of Neutrophil Extracellular Trap-Related Biomarkers in Diabetic Foot Ulcers Based on Bioinformatics.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neutrophil extracellular traps (NETs) play an important role in the development of diabetic foot ulcers (DFUs), and improving its progression by targeting the activation and regulation of NETs-related genes (NETRGs) might be an important therapeutic target and deserve further exploration. Methods: Differentially expressed NETRGs (DENETRGs) were obtained by intersecting the NETRGs and the differentially expressed genes (DEGs) between DFUs and healthy control (HC) samples. The nomogram was constructed with the biomarkers identified by machine learning algorithms. In addition, the immune infiltration was conducted to further analyze the pathogenesis of DFUs. We used quantitative real-time polymerase chain reaction (qRT-PCR) to verify the expression of the biomarkers. Results: Conclusion: This study revealed the potential molecular mechanisms of NETRGs in DFUs, which could provide novel insights for the clinical diagnosis and treatment of DFUs.
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