ArticleJournal of inflammation research2025
Positive Association Between the Ratio of Neutrophil to High-Density Lipoprotein Cholesterol and Diabetes Incidence: A Retrospective Cohort Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Systemic immuno-metabolic inflammatory indices (neutrophil-to-HDL cholesterol ratio and systemic inflammation response index) are strongly associated with metabolic dysfunction-associated steatotic liver disease: a propensity score-matched study.Frontiers in immunology · 2026Article
- Association Between Neutrophil-to-HDL Ratio and Full-Spectrum Dysglycemia: Insights from a Large Middle Eastern Population Study.Healthcare (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The neutrophil-to-high-density lipoprotein-cholesterol ratio (NHR) has been recommended as an alternative biomarker in metabolic syndrome and cardiovascular diseases such as coronary artery disease (CAD). However, there is a lack of data on the association between NHR and the incidence of diabetes. This study aimed to investigate the potential value of NHR as a predictor of incident diabetes among Chinese adults. Methods: This retrospective cohort study analyzed data from 16658 participants who had received annual health checkups at the Third Xiangya Hospital of Central South University from 2017 to 2024. The participants were split into four groups (Q1, Q2, Q3, and Q4) based on NHR levels. The cumulative diabetes incidence was assessed by Kaplan-Meier survival curves, compared using the Log rank test. The receiver operating characteristic (ROC) curve was used to calculate the optimal cut-off point of NHR for predicting diabetes risk. Multivariate Cox proportional hazards regression models were used to explore the association of the NHR and diabetes incidence. Results: A total of 12869 subjects were enrolled. The median follow‑up period was 5.1 years. An incrementally higher NHR was associated with an increasingly higher cumulative incidence of diabetes (Log rank test, p < 0.001). Compared to Q1, the fully adjusted HRs (95% CIs) of the Q2, Q3, and Q4 groups for new‑onset diabetes were 1.43 (0.81-2.53), 1.77 (1.03-3.06), and 2.80 (1.64-4.79), respectively. The AUCs obtained from receiver operating characteristic (ROC) analyses were 0.669 (95% CI: 0.63-0.70, p<0.001) for NHR. Based on the highest Youden's index, the optimal threshold was 3.25 for NHR. In addition, there were interactions between NHR and age (≥40), and adverse emotions (anxiety or depression) in subgroup analyses. Conclusion: The NHR was significantly associated with the incidence of diabetes, suggesting that the NHR may be a valid marker for risk stratification for T2DM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.