ArticleJournal of inflammation research2025
Age-Stratified Efficacy of Upadacitinib in Refractory Pediatric Crohn's Disease and Geriatric Ulcerative Colitis: An Asian Cohort Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Asian Pacific Association of Gastroenterology (APAGE) Clinical Practice Guidelines on the Use of Small Molecules and IL-23 p19 Inhibitors in Ulcerative Colitis and Crohn's Disease.Journal of gastroenterology and hepatology · 2026Guideline
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Inflammatory Bowel Disease presents significant management challenges, particularly in pediatric and elderly populations with refractory conditions. Despite advances in biologic therapies, current treatments remain limited with inconsistent response rates. This study investigated Upadacitinib efficacy in Asian adolescent and elderly populations with refractory IBD. Methods: This single-center, retrospective cohort study examined 21 patients at the Sixth Affiliated Hospital of Sun Yat-sen University: 11 pediatric refractory CD patients (aged 9-17) and 10 elderly refractory UC patients (aged 60+). Diagnoses were confirmed via comprehensive criteria including clinical symptoms, biomarkers, endoscopic findings, histological examination, and radiological results. Patients had refractory IBD, defined as failure of at least two biologic agents with distinct mechanisms or comorbid psychosocial complications impairing disease management. Results: Pediatric CD patients showed remarkable efficacy, with 72.7% achieving steroid-free clinical remission at week 12, maintained at 57.1% by week 24, and reaching 88.9% at final follow-up. Endoscopic remission improved from 50% at week 12 to 57.1% at final follow-up. Elderly UC patients showed modest outcomes, with 20% achieving clinical remission throughout the study. Laboratory parameters demonstrated significant improvements, particularly in C-reactive protein and albumin levels. The safety profile was generally favorable with minimal adverse events. Teenage CD patients experienced minor dermatological side effects, while UC patients showed no significant adverse events. One serious pneumonia case in the elderly group highlighted potential infection risks. Conclusion: This pioneering Asian study provides critical insights into UPA's potential as alternative treatment for challenging IBD cases in adolescent and elderly populations, demonstrating different efficacy and safety profiles across age groups and contributing evidence for personalized medicine approaches in managing refractory IBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.