Evidence map›Paper›PMID 40860916›Full record

ArticleFrontiers in veterinary science2025

Modified Huangqi Shengmai Yin enhances ruminal microbiome and metabolites activity in dairy cows with subclinical mastitis.

Chenyibo Zhang, Baoling Zhang, Yuqiong Li, John P Kastelic, Xiaoping Li, Xiaofang Tong, A Yao, Chuang Xu, Bo Han, Jian Gao

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In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Chenyibo ZhangDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Baoling ZhangDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Yuqiong LiInstitute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, China.
John P KastelicFaculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Xiaoping LiDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Xiaofang TongDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.
A YaoAnimal Health Supervision Institute, Lincang, China.
Chuang XuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Bo HanDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jian GaoDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Bovine mastitis, especially subclinical mastitis (SCM), with minimal clinical signs, is detrimental due to its resistance to treatment, recurrence, and substantial economic impact on global dairy industry. The modified form of Huangqi Shengmai Yin (HSY), classical traditional herbal medicine renowned for its effects in antimicrobial and circulatory-enhancing and thus beneficial for subclinical mastitis, has been developed for treatment attempt of SCM, yet its therapeutic effect and mechanism remains unclear. This study aims to investigate the therapeutic effects of mHSY on SCM in cows, and elucidate its potential therapeutic mechanism. Methods: In this study, mHSY was given orally to cows with SCM. After a 3-day treatment regimen, the therapeutic effects were evaluated. 16S diversity sequencing and metabolomics were used to elucidate the therapeutic mechanism of HSY. Results: The SCM was significantly alleviated after the 3-day treatment with HSY. In cows infected with SCM, there were significant alterations in rumen fluid microbiota, particularly proportions of Conclusion: mHSY shows significant inhibitory effects on SCM, which may be attributed to regulating ruminal microbiota and metabolic pathways

Indexed as

dairy cowsHuangqi Shengmai Yinmetabolites activitymicrobiome structuresubclinical bovine mastitis

Identifiers

PMID40860916
PMCPMC12370490

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.