ArticleThe Pan African medical journal2025
[Prevalence and associated factors of hyperuricemia in patients with type 2 diabetes in hospital settings in Dakar, Senegal].
Article in The Pan African medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: hyperuricemia increases cardiovascular morbidity and mortality in type 2 diabetes (T2D). The purpose of this study was to determine the prevalence of asymptomatic hyperuricemia in a population with type 2 diabetes and its determinants. Methods: we conducted a cross-sectional study at the Pikine National Hospital Center (CHNP) and the Abass Ndao Hospital Center (Dakar, Senegal). It involved outpatients with type 2 diabetes and without a history or symptoms of gout. Fasting blood samples were taken to measure metabolic parameters (uric acid, HbA1c, lipid profile, and magnesium levels). Results: the study included 90 patients. The mean age was 59,6 ± 8,8 years. There were 24 men and 66 women. The average duration of diabetes was 5 years, with a median HbA1c at inclusion of 7.2%. The prevalence of hyperuricemia was 31.1% (n=28). After multivariate analysis, the factors independently associated with hyperuricemia were male sex (adjusted odds ratio [aOR]: 3.9, 95% CI: 1,3-12,1; p=0,015), and GFR below 60 ml/min (aOR: 7.7, 95% CI: 1,2-48,3; p=0,029). A significant positive correlation was found between triglyceride levels and uric acid levels (r=0.5; p<0.001). Magnesium levels were inversely correlated with uric acid levels (r=-0,3; p=0,051). Conclusion: hyperuricemia is common in patients with type 2 diabetes. Screening is necessary, especially in male patients with impaired renal function and/or hypertriglyceridemia.
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