ArticleFrontiers in oncology2025
Clinical characteristics and surgical approach for pituitary granular cell tumors: a case series of six patients and literature review.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the clinical characteristics and therapeutic approaches for granular cell tumors (GCT) of the neurohypophysis. Materials and methods: Retrospective case series and analyzed the clinical data of six patients with histopathologically confirmed GCT of the neurohypophysis, also conducting a simple review of relevant literature. Results: The median age at diagnosis for the cohort of six patients was 41.0 ± 11.73 years, with an age range of 21.8 to 52.7 years. A predominance of female patients was noted, accounting for five out of six cases. The most common clinical symptoms were headache and visual disturbances, each reported in five of the six patients. Magnetic resonance imaging (MRI) of the brain predominantly revealed a rounded morphology, and well-defined boundaries. Of these tumors, two were located in the suprasellar region while four were situated within the sellar region, encompassing intrasellar, suprasellar, and parasellar locations. Contrast-enhanced MRI demonstrated heterogeneous enhancement in four cases and homogeneous enhancement in two cases. Surgical intervention, either through a neuro-endoscopic endonasal transsphenoidal approach or craniotomy, achieved total or subtotal tumor resection in all patients. Postoperative histopathological examination confirmed the diagnosis of GCT in each instance. All patients participated in follow-up evaluations, during which varying degrees of clinical symptom improvement were documented. Importantly, none of the four patients who underwent complete tumor resection exhibited recurrence or metastasis. Conclusion: GCT of the neurohypophysis are rarely encountered clinical practice. The definitive diagnosis of GCT primarily relies on histopathological evaluation. Currently, the standard therapeutic approach involves complete surgical excision of the tumor using a neuroendoscopic endonasal transsphenoidal technique. Post-resection, the rates of recurrence and metastasis are significantly low.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.