SynthesisFrontiers in oncology2025
A systematic review and exploration of clinical application of liver depression syndrome in breast cancer.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of bupleurum-containing formulas combined with chemotherapy for triple-negative breast cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Multi-omics graph attention network reveals neuro-immune-tumor pathways in breast cancer liver depression syndrome.Frontiers in immunology · 2026Trial
- Association between the fear of cancer recurrence and Traditional Chinese Medicine constitution in breast cancer patients: a cross-sectional study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Shu Gan Jie Yu herbal combination enhances tamoxifen sensitivity in breast cancer cells via modulation of the SNCG/Frontiers in pharmacology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer remains one of the most prevalent malignancies among women. Traditional Chinese Medicine (TCM) identifies Liver depression syndrome as a core clinical pattern in breast cancer; however, the absence of systematic reviews addressing this specific syndrome has constrained the development and application of TCM interventions. This systematic review searched seven Chinese and English databases, and was supplemented by published books and clinical guidelines, to identify literature documenting TCM diagnostic indicators of Liver depression syndrome in breast cancer. The collated data formed the TCM item for Liver depression syndrome in breast cancer, and descriptive statistics were applied to analyze symptom patterns. This study revealed 104 distinct clinical manifestations and 56 tongue-pulse indicators. The predominant syndrome subtypes included syndrome of Systematic review registration: https://www.crd.york.ac.uk/prospero, identifier CRD42024546784.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.