ArticleFrontiers in oncology2025
To explore the prognostic efficacy and mechanism of ABCC5 clinical scoring model in hepatocellular carcinoma.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Objective: The study found that ATP-binding cassette subfamily C member 5 (ABCC5) is highly expressed in hepatocellular carcinoma (HCC). It aims to explore ABCC5 role and prognostic value in HCC and uses the DrugBank database to identify potential therapeutic drugs targeting ABCC5, assessing its potential as a biomarker and treatment target for HCC. Methods: RNA-seq and clinical data from TCGA-LIHC and GSE76427 were analyzed to identify ABCC5-associated differentially expressed genes and miRNAs. Weighted gene co-expression network analysis (WGCNA) revealed co-expression modules, and survival analysis assessed prognostic significance. Experimental validation included qRT-PCR, Western blot, migration assays, and drug response studies using the ABCC5 inhibitor zidovudine (ZDV). Result: ABCC5 was significantly overexpressed in HCC ( Conclusion: This study constructed an ABCC5 clinical model and discovered that ABCC5 can serve as both a prognostic biomarker and therapeutic target for HCC. Multi-omics analysis and experimental validation confirmed that ABCC5 drives HCC progression by participating in immune microenvironment reprogramming, affecting cell cycle progression, and regulating the p53 signaling pathway. The research not only identified potential diagnostic markers and therapeutic targets, but the established prognostic model also provides new insights for investigating HCC pathogenesis and clinical translation.
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