Evidence map›Paper›PMID 40860792›Full record

ArticleFrontiers in oral health2025

Calcium, phosphate and fluoride ionic release from dental restorative materials for elderly population: an

Angelo Aliberti, Franklin Garcia-Godoy, Alexandre Luiz Souto Borges, João Paulo Mendes Tribst, Roberta Gasparro, Mauro Mariniello, Pietro Ausiello

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07598305 (Polymer-Infiltrated Ceramic Network Versus Smart Bioactive Self-Curing Composite for Cervical Restorations in Profession-al Ballet Dancers), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07598305 nacompletednot on this map

Polymer-Infiltrated Ceramic Network Versus Smart Bioactive Self-Curing Composite for Cervical Restorations in Profession-al Ballet Dancers: A 24-Month Split-Mouth Randomized Controlled Trial

TypeinterventionalSponsorI.M. Sechenov First Moscow State Medical UniversityRan2021 to 2024Enrolled20ConditionsBallet Dancers, Caries, CervicalArmsPolymer-infiltrated ceramic network (PICN) - carious, Polymer-infiltrated ceramic network (PICN) - abfraction, Self-curing bioactive bulk-fill composite - carious, Self-curing bioactive bulk-fill composite - abfraction
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Frontiers in dental medicine · 2026
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Angelo AlibertiDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
Franklin Garcia-GodoyDepartment of Bioscience Research, College of Dentistry-University of Tennessee Health Science Center, Memphis, TN, United States.
Alexandre Luiz Souto BorgesDepartment of Dental Materials and Prosthodontics, Institute of Science and Technology, São Paulo State University (Unesp), Sao Paulo, Brazil.
João Paulo Mendes TribstDepartment of Reconstructive Oral Care, Academic Centre for Dentistry Amsterdam (ACTA), Universiteit van Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Roberta GasparroDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
Mauro MarinielloDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
Pietro AusielloDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: With the increasing prevalence of cervical and root lesions in elderly patients, dental filling materials able to release bioactive ions are gaining importance in the restorative treatment. This study evaluated the release of calcium (Ca Methods: Specimens (10 mm diameter and 2 mm thickness; Results: Ion release from dental restorative materials was significantly influenced by pH, temperature, and exposure duration. All materials tested exhibited consistent pH trends, with an increase in acidic conditions and stabilization in neutral and basic environments. Fluoride release was notably affected by pH and exposure time ( Conclusions: The study highlights the relevance of ion-releasing from some bioactive dental restorative materials commonly employed also for managing Class V cervical lesions and promote remineralization in aging oral environments. Materials tested showed variable fluoride, calcium, and phosphate release depending on pH, temperature, and time.

Indexed as

bioactive dental materialscalciumfluorideglass ionomer cementsionic releasephosphateresin compositerestorative materials

Identifiers

PMID40860792
PMCPMC12375625

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.