ArticleEndoscopy international open2025
Safety and efficacy of peroral endoscopic myotomy with endoscopic fundoplication compared with POEM alone: International multicenter cohort study.
Article in Endoscopy international open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
20 authors.
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Abstract
Background and study aims: Gastroesophageal reflux (GERD) can occur in a significant number of achalasia patients undergoing post-peroral endoscopic myotomy (POEM). POEM with endoscopic fundoplication (POEM-F) is a new endoscopic technique to treat post- POEM GERD. We conducted a multicenter cohort study to compare outcomes between POEM and POEM-F. Patients and methods: We included patients who underwent POEM or POEM-F from six tertiary centers. Primary outcomes were: 1) clinical success, defined as post-procedure cessation or reduction of proton-pump inhibitors; 2) post procedure percent time pH < 4 and DeMeester score; and 3) post-procedure Eckardt scores. Secondary outcomes included adverse events, procedure time, and hospital stay duration. Results: Sixty-four patients were included: 31 patients underwent POEM-F (mean age 51, 48% male), whereas 33 patients POEM (mean age 56, 58% male). Technical success was 100% in both groups. POEM-F patients achieved reduction/cessation in proton pump inhibitor use in 25 of 31 patients (80%); POEM patients in eight of 33 (24%) ( Conclusions: POEM-F achieves statistically significant improvement in post- POEM GERD compared with POEM alone.
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