ArticleFrontiers in allergy2025
Mitochondrial haplogroup M contributes to asthma risk in the Kuwaiti population.
Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Asthma is a multifactorial chronic inflammatory disease characterized by intermittent airflow obstruction, which may result in irreversible pathological remodelling of the airways. In Kuwait, the prevalence of asthma among young adults is approximately 11%, with a strong maternal influence on asthma risk. While nuclear genetic studies have identified several asthma-associated loci, the role of maternally inherited mitochondrial DNA (mtDNA) in asthma susceptibility remains poorly understood, particularly in Middle Eastern populations. Methods: In this exploratory study, we analysed mtDNA from 287 Kuwaiti individuals, including 48 asthmatics and 239 controls, extracted from whole-exome sequencing data (average coverage 27×), with variant calling via GATK and haplogroup assignment using HaploGrep2. Logistic regression was used to assess associations between mtDNA variants/haplogroups and asthma, adjusting for age, sex, and BMI. Results: Mitochondrial haplogroup M was identified as a significant risk factor for asthma (OR = 3.37; 95% CI = 1.09-10.42; Conclusions: Our findings suggest that mitochondrial haplogroup M and specific mtDNA variants contribute to asthma susceptibility in the Kuwaiti population. These insights provide a foundation for future research on mitochondrial genetic influences in asthma and highlight the need for larger studies to validate these associations and explore potential therapeutic implications.
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