ArticleACS engineering Au2025
Process and Formulation Parameters Governing Polymeric Microparticle Formation via Sequential NanoPrecipitation (SNaP).
Article in ACS engineering Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain.Biomaterials · 2026Article
- A Comparative Study of Flash Nanoprecipitation and Sequential Nanoprecipitation: Impact of Formulation Parameters on Drug-Loaded Nanoparticle Formation.Molecular pharmaceutics · 2025Article
- Engineering Nanoscale Drug Delivery Systems for Pain.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymeric microparticles (MPs) are valuable drug delivery vehicles for extended-release applications, but current manufacturing techniques present significant challenges in balancing size control with scalability. Industrial synthesis processes provide high throughput but limited precision, while laboratory-scale technologies offer precise control but poor scalability. This study explores Sequential NanoPrecipitation (SNaP), a two-step controlled precipitation process for polymeric microparticle production, to bridge the gap between laboratory precision and industrial scalability. We systematically investigated critical process parameters governing MP formation, focusing on poly-(lactic acid) (PLA) MPs stabilized with poly-(vinyl alcohol) (PVA). By comparing vortex and impinging jet mixing geometries, we demonstrated that vortex mixing provides superior performance for core assembly, particularly at higher polymer concentrations. We established the influence of delay time (
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Registered trials
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