ArticlePatient preference and adherence2025
Exploring the Factors Related to Medication Adherence in Patients with Rheumatoid Arthritis Based on Social Cognitive Theory: A Path Analysis.
Article in Patient preference and adherence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Learning to live with RA as an unwelcome companion-patients' experiences after 1 to 2 years of DMARD treatment.EULAR rheumatology open · 2026Article
- Lifestyle Behaviours and Antiplatelet Medication Adherence Among Post-Percutaneous Coronary Intervention Patients in Saudi Arabia: Implications for Holistic Cardiovascular Nursing Care.Healthcare (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
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Abstract
Background: Studies have shown that poor medication adherence is common in patients with rheumatoid arthritis (RA). However, the related factors and underlying mechanisms remain unclear. Through theory-based research, the mechanism of medication adherence in RA patients can be better explored and clarified, providing reference for clinical intervention. Aim: To explore the mediating role of medication self-efficacy between perceived barriers, pharmacologic treatment expectations, social support and medication adherence in patients with RA based on the social cognitive theory. Methods: A total of 232 participants diagnosed with RA were recruited from three general hospitals in Guangzhou, China. Participants' sociodemographic, disease-, and medication-related information as well as data on their perceived barriers, pharmacologic treatment expectations, social support, medication self-efficacy, and adherence were collected. SPSS 25.0 software was used for univariate analysis of medication adherence and to explore the correlation between variables. Mplus 8.0 was used to build a parallel mediation model and perform path analysis. Results: In addition to pharmacologic treatment expectations, perceived barriers, family support, and medication self-efficacy were associated with medication adherence. A mediating model with three independent variables showed that medication self-efficacy fully mediated the negative impact of perceived barriers on medication adherence. Family support had a positive effect on both medication adherence and self-efficacy, but it did not affect medication adherence through medication self-efficacy. Conclusion: Medication self-efficacy, as a mediating factor, plays a key role in improving medication adherence of RA patients. In nursing practice, timely assessment of the actual or potential barriers on medication adherence of patients and implementation of targeted intervention measures such as health education, as well as giving full play to the positive role of the family support system to improve patients' medication self-efficacy, will effectively enhance the medication adherence of patients with RA.
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