Evidence map›Paper›PMID 40860570›Full record

ArticleJCEM case reports2025

Long-Term Clinical Experience With Metreleptin in a Brazilian Patient With Congenital Generalized Lipodystrophy Type 2.

Isabella Sued Leão, Joana Rodrigues Dantas, Sarah Galvão, Melanie Rodacki, Lenita Zajdenverg

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isabella Sued LeãoMedical Clinic Department, Nutrology and Diabetes Unit, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil.ORCID https://orcid.org/0000-0001-6618-4816
Joana Rodrigues DantasMedical Clinic Department, Nutrology and Diabetes Unit, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil.
Sarah GalvãoMedical Clinic Department, Endocrinology Unit, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil.
Melanie RodackiMedical Clinic Department, Nutrology and Diabetes Unit, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil.
Lenita ZajdenvergMedical Clinic Department, Nutrology and Diabetes Unit, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe our 8-year clinical experience with metreleptin in a Brazilian adult female patient with congenital generalized lipodystrophy type 2 (due to a mutation in the

Indexed as

congenital generalized lipodystrophyglycemic controlleptin replacement therapymetabolic complicationsmetreleptin

Identifiers

PMID40860570
PMCPMC12371232

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.